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Product title :

Production and calibration of the second batch of OIE anti-rabies positive reference serum

Author(s) : M. Wasniewski, J. Barrat, A.R. Fooks, R. Franka, T. Müller, C. Sabeta & F. Cliquet

Summary :

The Biological Standards Commission of the World Organisation for Animal Health (OIE) oversees the preparation and validation of OIE-approved International Reference Standards for use in serological assays for detecting infectious diseases of animals or the adequacy of their immune response following vaccination against those diseases. The principal use of OIE-approved International Reference Standards is to harmonise serological testing and to promote the mutual recognition of test results for international trade. In the OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, the organisation recommends the use of the OIE anti-rabies positive reference serum of dog origin to titrate serum samples in international units (IU)/ml for use in rabies serological tests. The first batch of OIE reference serum of dog origin was produced in1991 and was used internationally until the beginning of 2010.

Keywords

Dog – Fluorescent antibody virus neutralisation test – Inter-laboratory test – International reference standard – Rabies – Rabies-neutralising antibodies – Rapid fluorescent focus inhibition test.

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