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|Author(s) :||J.F. Acar & G. Moulin|
We trust that, by examining the latest information available, this edition of the OIE Scientific and Technical Review will provide an objective basis for a proper understanding of the problem of the resistance of bacteria to antimicrobial agents. Nevertheless, many questions still remain unanswered. Microbial ecology and the reversible and irreversible changes caused by the use of antibiotics are areas of knowledge that have been insufficiently explored. We know that bacteria respond to the use of antibiotics by developing resistance, and that the prevalence and diversity of this resistance depend on the concentration and the ecological context of the bacterial population in question. However, our current state of knowledge makes it difficult to predict how this bacterial response will change if the use of antibiotics is reduced, so further work is required in these domains.